Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Prof. Timothy O'Brien

Phone: 
+353 91 495107
timothy.obrien@nuigalway.ie

Director of REMEDI

Development of gene and cell therapy approaches to vascular disease with a special focus on the augmentation of nitric oxide bioavailability.

Researcher in

Research Project Area: 

Professor O'Brien established the Regenerative Medicine Institute at NUI, Galway (REMEDI).  The focus of the Institute is to exploit the synergies between the technologies of gene delivery and stem cell biology to promote organ regeneration and repair.  The principal initial disease targets of the Institute are ischaemic cardiovascular disease and osteoarthritis.

NO bioavailability

NO bioavailability is diminished in a variety of vascular disease states such as hypertension, hyperlipidemia and diabetic wounds. Prof. O'Brien is interested in a therapeutic approach to these disorders using gene and or cell therapy. The gene therapy approach has focused on targeted expression of nitric oxide isoforms in the diseased vessel site and the use of endothelial progenitor cells as a gene delivery system. Prof. O'Brien also has an interest in the pathogenesis of diabetic vascular disease including the role of endothelial progenitor cell dysfunction.

Positions Held: 

2004-present
Director of the Regenerative Medicine Institute, NUI, Galway and GUH

2001- present
Professor and Head of Medicine, Consultant Endocrinologist
NUIG and Galway University Hospital

1995-2001
Consultant
Division of Endocrinology, Nutrition and Metabolism, Mayo Clinic, Rochester, Minnesota, USA

1999-2001
Associate Professor of Medicine
Mayo Foundation, Rochester, Minnesota, USA

1995-1999
Assistant Professor of Medicine
Mayo Graduate School of Medicine, Rochester, MN, USA

1993-1994
Postdoctoral Fellow
Gladstone Institute of Cardiovascular Disease, San Francisco

1993-1994
Assistant Clinical Professor of Medicine
University of California, San Francisco, USA

1990-1992
Fellow in Endocrinology and Metabolism
Mayo Graduate School of Medicine, Rochester, MN, USA

1988-1990
Resident in Internal Medicine
Medical College of Wisconsin, Milwaukee, WI, USA

1984-1988
Resident in Internal Medicine
Cork Regional Hospital

 

Education/Qualifications

1996
Ph.D
National University of Ireland, Cork

1990
M.D
National University of Ireland, Cork

1987
MRCP (UK)
Royal College of Physicians, UK

1986
MRCPI Part 2
Royal College of Physicians of Ireland

1986
MRCPI Part 1
Royal College of Physicians of Ireland

Awards & Honours: 

1978
College Scholar; University College Cork
1988
Ainsworth Scholarship; University College Cork
1991-1992
WL Stephenson Fellowship in Clinical Nutrition; Mayo Graduate School of Medicine
1993-1994
Mayo Foundation Scholar; Mayo Graduate School of Medicine
1993
Sprague Award for Excellence in Clinical Medicine; Division of Endocrinology and Metabolism, Mayo Clinic
1997
Outstanding Poster Presentation. Internal Medicine Research Activities Forum, Mayo Clinic
1998
Young Investigator Award. Vascular and Myocardial Aspects of Ischemic Heart Disease. American Heart Association.
1998
Mayo Clinic Internal Medicine Research Award: Adipocyte Macrophage Colony Stimulating Factor (MCSF) Is a mediator of adipose tissue growth.

2005
Stokes Medal, Irish Cardiac Society
2007
Nordisk Lecture, Irish Endocrine Society
2008
48th Graves lecture of the Royal academy of Medicine in Ireland 
2009                                                                                                    Mayne Lecture, Trinity College Dublin (TCD)

Selected Publications: 

 PubMed Link:                                                         http://www.ncbi.nlm.nih.gov/pubmed?term=O'Brien%20T%20Galway

 

Khurana VG, Smith LA, Baker TA, Eguchi D, O’Brien T, Katusic ZS.  Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm.  Stroke 33: 782-789, 2002. Impact Factor  6.499. Cited 36.

 

Zanetti M, Sato J, Katusic ZS, O’Brien T.  Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta.  Am J Physiol Heart Circ Physiol 280:H2516-H2523, 2001. Impact Factor 3.643. Cited 32.

 

Sato J, Nair KS, Hiddinga J, Eberhardt NE, Fitzpatrick LA, Katusic ZS, O’Brien T. eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis.  Cardiovasc Res 47(4):697-706, 2000. Impact Factor 5.947. Cited 45.

 

Cable DG, Caccitolo JA, Caplice N, O’Brien T, Simari RD, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV.  The role of gene therapy for intimal hyperplasia of bypass grafts.  Circulation 100: II-392-II-396, 1999. Impact Factor 14.595. Cited 34.

 

Onoue H, Tsutsui M, Smith L, Stelter A, O’Brien T, Katusic Z.  Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage.  Stroke. 28(9):1959-1965, 1998. Impact Factor 6.499. Cited 47.

 

Levine JA, Jensen MD, Eberhardt NL, O'Brien T.  Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth.  J Clin Invest. 101:1557-1564, 1998. Impact Factor 16.559. Cited 64.

 

Kullo IJ, Mozes G, Schwartz RS, Gloviczki P, Tsutsui M, Katusic ZS, O'Brien T.  Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries.  Hypertension. 30: 314-320, 1997. Impact Factor 7.368. Cited 56.

 

Kullo IJ, Mozes G, Schwartz R, Gloviczki P, Crotty TB, Barber DA, Katusic ZS, O'Brien T.  Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity.  Circulation.  96: 2254-61, 1997. Impact Factor14.595. Cited 61.

 

Chen AFY, Jiang SW, Crotty TB, Tsutsui M, Smith LA, O'Brien T, Katusic ZS. Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries.  Proc Natl Acad Sci USA.  94: 12568-12573, 1997. Impact Factor 9.38. Cited 73.

 

Chen AF, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS.  Expression and function of recombinant endothelial nitric oxide synthase gene in the canine basilar artery.  Circulation Research. 80: 327-335, 1997. Impact Factor 9.989. Cited 88.

 

Recent Publications  

 

 Holohan, C, Szegezdi, E, Ritter, T, O’Brien, T, Samali, A. Cytokine-induced Beta-Cell Apoptosis is no-dependent, mitochondria-mediated and inhibited by BCL-XL. J Cell Mol Med. 2008 Apr;12(2):591-606. Epub 2007 Dec 10.

 

Reeve, J, Stenson-Cox, C, O’Doherty, A, Porn-Ares, I, Ares, M, O’Brien, T, Samali, A. OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/-mice aortas. Biochemical and Biophysical Research Communications 356 (3) 681-6, 2007.

 

Reeve JL, Szegezdi E, Logue SE, Chonaighle TN, O’Brien T, Ritter T, Samali A.  Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL.  J Cell Mol Med. 2007 May-Jun;11(3):509-20.

 

Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O’Brien T,  Kerin MJ. Monocyte Chemotactic Protein-1 (MCP-1) secreted by primary breast tumors stimulates migration of Mesenchymal Stem Cells (MSCs). Clinical Cancer Research (2007) 13 (17): 5020-5027.

 

Stender S, Murphy M, O’Brien T, Stengaard C, Ulrich-Vinther M, Soballe K, Barry F.  Adeno-associated viral vector transduction of human mesenchymal stem cells.  Eur Cell Mater. 2007 May 31;13:93-9; discussion 99.

 

Rao, VP, Branzoli SE, Miyagi N, O’Brien, T, Tazelaar HD, Russell SJ, McGregor CG. Recombinant adenoviral gene transfer does not affect cardiac allograft vasculopathy.  J Heart Lung Transplant. 2007 Dec:26(12):1281-5.

 

Rooney, G.E., Moran, C., McMahon, S.S., Ritter, T., Maenz, M., Flügel, A., Dockery, P., O’ Brien, T., Howard, L., Windebank, A.J. , Barry, F.P.  Gene-Modified Mesenchymal Stem Cells express functionally active Nerve Growth Factor on an engineered poly lactic glycolic acid (PLGA) substrate.  Tissue Eng Part A. 2008 May;14(5):681-90.

 

Sen S, Conroy S, Hynes SO, McMahon J, O'Doherty A, Bartlett JS, Akhtar Y, Adegbola T, Connolly CE, Sultan S, Barry F, Katusic ZS, O'Brien T.  Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5. J Gene Med. 2008 Feb;10(2):143-51

 

Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien, T.  Gene Eluting Stents: Adenoviral-Mediated Delivery of eNOS to the Blood Vessel Wall Accelerates Re-Endothelialization and Inhibits Restenosis. Mol Ther. 2008 Oct;16(10):1674-80. Epub 2008 Aug 19.

 

Mohr A, Lyons M, Deedigan L, Harte T, Shaw G, Howard L, Barry F, O'Brien T, Zwacka R. Mesenchymal Stem Cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model. J Cell Mol Med. 12 (6b); 2628-2643 Dec 2008.

 

Rooney, G.E., Howard, L., O’ Brien, T., Windebank, A. J., Barry, F.P.  Elevation of cAMP Induces Transient Upregulation of Neural Markers in Mesenchymal Stem Cells Cultured in a Defined Element Serum-Free Environment. Stem Cells Dev. 2008 Jun 13.

 

Breen, A., Dockery, P., O’Brien, T., and Pandit, A. Fibrin Scaffold Promotes Adenoviral Gene Transfer and Controlled Vector Delivery.   J Biomed Mater Res A. 2008 May 8.

 

Mylotte LA, Duffy AM, Murphy M, O'Brien T, Samali A, Barry F, Szegezdi E. Metabolic flexibility permits MSC survival in an ischemic environment.  Stem Cells. 2008 May;26(5):1325-36. Epub 2008 Feb 28


Breen, A, Dockery A, O' Brien T. and Pandit A. The use of Therapeutic Gene eNOS delivered via a Fibrin Scaffold Enhances Wound Healing in a Compromised Wound Model. Biomaterials.   2008 Jul;29(21):3143-51. Epub 2008 Apr 28.

 

Gilbert, J. Purcell, J. Strappe, P. McCabe, M. O’Brien, T. O’Dea, S. Comparative evaluation of viral, non-viral and physical methods of gene delivery to normal and transformed lung epithelial cells. Anticancer Drugs. 2008 Sep;19(8):783-8.

 

Molloy AP, Dwyer RM, Martin FT, Griffin TP, Murphy JM, Barry FP, O’Brien T, Kerin MJ. (2008) Mesenchymal Stem Cell (MSC) secretion of chemokines during differentiation  into Osteoblasts, and their potential role in mediating interactions with breast cancer cells.  International Journal of Cancer. 2009 Jan15;124(20:326-32.

 

Breen A, Mc Redmond G, Dockery P, O’Brien T, Pandit A (2008). Assessment of Wound Healing in the Alloxan Induced Diabetic Rabbit Ear Model. J Invest Surg. 2008 Sep-Oct; 21(5): 261-9.

 

Kealy, B, Liew, A, McMahon, JM, Ritter, T, O’Doherty, A, Hoare, M, Greiser, U, Maenz,  M,  O’Shea, C, Barry FP, O’Brien T. Comparison of viral and non-viral vectors for gene transfer to human endothelial progenitor cells. Tissue Eng Part C Methods, 2009 Jun; 15(2): 223-31.

 

MacLoughlin, RJ, Higgins, BD, Laffey JG, O’Brien, T. Optimized Aerosol Delivery to a Mechanically Ventilatd Rodent. Journal of Aerosol Medicine and Pulmonary drug delivery, vol 22, number 3, 2009.

 

Duffy GP, Ahsan T, O’Brien T, Barry FP M. Nerem RM (2008).  Bone Marrow Derived Mesenchymal Stem Cells Promote Angiogenic Processes in a Time and Dose Dependent Manner In vitro.. Tissue Engineering, 2009 Sep; 15(9):2459-70.

 

Rooney, GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Fluegel A, Dockery P, O’Brien T, Howard L, Windebank AJ, Barry F. Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells. Tissue Eng.2009 Oct:15(10):3049-59.

 

Kulkarni M, Breen A, Greiser U, O’Brien T, Pandit A. Fibrin-Lipoplex System for Controlled Topical Delivery of Multiple Genes. Biomacromolecules 2009 jun 8; 10(6): 1650-4.

 

Rooney GE, Howard L, O’Brien T, Windebank AJ, Barry FP. Elevation of cAMP n mesenchymal stem cellls transiently upregulates neural markers rather than inducing neural differentiation. Stem Cells Dev. 2009 Apr; 18(3):387-98.

 

O’Loughlin A, Waldron-Lynch F, Cronin KC, Dineen S, Lee J, Griffin D, Casey M, Nusrat N, Jaffrey S, O’Brien T, Dunne F. When a nephrectomy cures hypoglycaemia. BMJ Case reports 2009 (epub ahead of time).

 

Halloday C, Keeney M, Greiser U, Murphy M, O’Brien T, Pandit A. A matrix reservoir for improved control of non-viral gene delivery.  Journal of Controlled Release  2009 Jun 19; 136(3): 220-5.

 

Kulkarni M, Breen A, Greiser U, O’Brien T, Pandit A.  Fibrin-Lipoplex System for Controlled Topical Delivery of Multiple Genes.  Biomacromolecules 2009 June :10(6):1650-4

 

Madsen D, Cantwell ER, O’Brien T, Johnson PA, Mahon BP. AAV-2 induces cell mediated immune responses directed against multiple epitopes of the capsid protein VP1. J Gen Virol. 2009 Nov;90 (Pt 11):2622-33

 

McMahon SS, Albermann S, Rooney GE, Moran C, O’Brien T, Hynes J, Garcia Y, Dockery P, Windebank AJ, Barry FB. Effect of Cyclosporin A on functional recovery in the spinal cord following contusion injury.  J Anat 2009 Sept:215(3):267-79.

 

O’Toole D, Hassett P, Contreras M, Higgins DB, McKeown STW, McAuley DF, O’Brien T, Laffey JG. Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-ĸB dependent mechanism.  Thorax. 2009 Nov;64(11):976-82.

 

Eglon M, Duffy AM, O’Brien T, Strappe PM.  Purification of adenoviral vectors by combined anion exchange and get filtration chromatography. J Gene Med. 2009 Nov;11(11):978-89.

 

Madigan NN, O’Brien T, Yaszemski MJ, Windebank AJ.  Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds.  Respir Physiol Neurobiol. 2009 Nov 30;169(2):183-99.

 

Kubiak C, De Andres-Trelles F, Kuchinke W, Huemer KH, Thirstrup S, Whitfield K, Libersa C, Barraud B, Grahlert X, Dreier G, Grychtol R, Temesvari Z, Blasko G, Kardos G, O’Brien T, Cooney M, Gaynor S, Schieppati A, Sanz N, Hernandez R, Asker-Hagelberg C, Johansson H, Bourne S, Byrne J, Asghar A, Husson JM, Gluud C, Demotes-Mainard J.  Common definition for categories of clinical reseach: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN). Trials. 2009 Oct 16;10:95.

 

Hoare M, Greiser U, Schu S, Mashayekhi K, Aydogan E, Murphy M, Barry F, Ritter T, O'Brien T. Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides. J Gene Med. 2010 Feb;12(2):207-18. 

 

Martin FT, Dwyer RM, Kelly J, Murphy JM, Curran C, Miller N, Hennessy E, Dockery P, Barry FP, O’Brien T, Kerin MJ. Potential Role of Mesenchymal Stem Cells (MSCs) in the Breast Tumor Microenvironment: Stimulation of Epithelial to Mesenchymal Transition (EMT).  Breast Cancer Research and Treatment. 2010 Jan 20. 

 

 O'Shea CA, Hynes SO, Shaw G, Coen BA, Hynes AC, McMahon J, Murphy M, Barry F, O'Brien T. Bolus delivery of mesenchymal stem cells to injured vasculature in the rabbit carotid artery produces a dysfunctional endothelium. Tissue Eng Part A. 2010 May;16(5):1657-65.  

 

Duffy AM, O'Brien T, McMahon JM. Generation of antioxidant adenovirus gene transfer vectors encoding CuZnSOD, MnSOD, and catalase. Methods Mol Biol. 2010;594:381-93. 

 

 Eglon M, McGrath B, O'Brien T. HPLC purification of adenoviral vectors. Methods Mol Biol. 2010;594:395-408. PMID:20072933

 

McMahon SS, Albermann S, Rooney GE, Shaw G, Garcia Y, Sweeney E, Hynes J, Dockery P, O'Brien T, Windebank AJ, Allsopp TE, Barry FP. Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury. Cytotherapy. 2010 May;12(3):313-25.  

 

Duffy GP, D'Arcy S, Ahsan T, Nerem RM, O'Brien T, Barry F.Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential. Tissue Eng Part A. 2010 Sep;16(9):2755-68.

 

 Dwyer RM, Khan S, Barry FP, O'Brien T, Kerin MJ. Advances in mesenchymal stem cell-mediated gene therapy for cancer. Stem Cell Res Ther. 2010 Aug 9;1(3):25. PMID:20699014[PubMed - in process]

 

Donnelly EM, Strappe PM, McGinley LM, Madigan NN, Geurts E, Rooney GE, Windebank AJ, Fraher J, Dockery P, O'Brien T, McMahon SS.  Lentiviral vector-mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. J Gene Med. 2010 Nov;12(11):863-72. doi: 10.1002/jgm.1509. Epub 2010 Oct 26.

 

Hoare M, Greiser U, Schu S, Mashayekhi K, Aydogan E, Murphy M, Barry FB, Ritter T, O’Brien T. Enhanced lipoplex-mediatd gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides. J. Gene Med. 2010 Feb;12(2):207-18.

 

 Hynes SO, McCabe C, O'Brien T. β cell protection by inhibition of iNOS through lentiviral vector-based strategies. Methods Mol Biol. 2011;704:153-68.  PMID:21161636

 

Kulkarni MM, Greiser U, O'Brien T, Pandit A. A Temporal Gene Delivery System Based on Fibrin Microspheres.  Mol Pharm. 2011 Jan 12. [Epub ahead of print]  PMID:21171649

 

 Flynn A, O'Brien T.  Stem cell therapy for cardiac disease. Expert Opin Biol Ther. 2011 Feb;11(2):177-87.  PMID:21219235

 

Holladay C, Power K, Sefton M, O'Brien T, Gallagher WM, Pandit A.  Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo.  Mol Ther. 2011 Jan 25. [Epub ahead of print]PMID:21266957

 

Heneghan HM, Miller N, McAnena OJ, O'Brien T, Kerin MJ. Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers. J Clin Endocrinol Metab. 2011 Mar 2. [Epub ahead of print] PMID: 21367929

 

Dwyer RM, Ryan J, Havelin RJ, Morris JC, Miller BW, Liu Z, Flavin R, O'Flatharta C, Foley MJ, Barrett HH, Murphy JM, Barry FP, O'Brien T, Kerin MJ.  Mesenchymal Stem Cell (Msc) Mediated Delivery of the Sodium Iodide Symporter (Nis) Supports Radionuclide Imaging and Treatment of Breast Cancer. Stem Cells. 2011 May 23. doi: 10.1002/stem.665. [Epub ahead of print]  PMID: 21608083

 

Recent Review Articles

Liew, A, McDermott, J.H, Barry, F, O’Brien, T. Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or pandora’s box? Diabetes Obes Metab. 2007 Sep 6;. 

Gaffney, MM, Hynes, SO, Barry, F, O’Brien, T. Cardiovascular gene therapy: current status and therapeutic potential. British journal of Pharmacology (2007) 152, 175-188. This article was downloaded (either in pdf or html form) a total of 1,857 times by online subscribers over the 3 months post-publication, the largest number of downloads of all the papers in this issue of BJP.

Flynn A, Barry F, O’Brien T. UC-blood derived mesenchymal stromal cells: an overview. Cytotherapy 9(8):7127-726 Oct 2007.

McCabe C, O’Brien T. The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression. Mol Biotechnol 37(1):33-47 Sep 2007.

Flynn, A, O’Brien, T. Alferminogene Tadenovac, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs 2008 11 (4): © The Thomson Corporation ISSN 1369-7056. 
 

Holladay CA, O'Brien T, Pandit A. Non-viral gene therapy for myocardial engineering. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun;2(3):232-48. Review. PMID:20063367
 

Mieske K, Flaherty G, O'Brien T. Journeys to high altitude--risks and recommendations for travelers with preexisting medical conditions.J Travel Med. 2010 Jan-Feb;17(1):48-62. Review.

Griffin M, Greiser U, Barry F, O'Brien T, Ritter T. Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease. Discov Med. 2010 Mar;9(46):219-23. Review. PMID:203504886

O'Loughlin A, McIntosh C, Dinneen SF, O'Brien T. Review paper: basic concepts to novel therapies: a review of the diabetic foot. Int J Low Extrem Wounds. 2010 Jun;9(2):90-102. Review. PMID:20483808 
 

Moran CJ, Shannon FJ, Barry FP, O'Byrne JM, O'Brien T, Curtin W. Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention. J Bone Joint Surg Br. 2010 Sep;92(9):1195-202. Review.

 Locke P, O'Brien T, Tuan RS. Stem Cell Research & Therapy marks its first anniversary. Stem Cell Res Ther. 2011 May 6;2(3):22. [Epub ahead of print]  PMID: 21554748 
 

 

Research Funding: 

Science Foundation Ireland: Principal Investigator for Regenerative Medicine Institue (REMEDI).
From Research to Human Therapy €7,456,432 – direct costs. 2010-2015.
 

Enterprise Ireland: PI Development of Liposomal Gene Transfer using a stent based platform. 2007-2010. €489,993.

Health Research Board: Co-investigator Regeneration of injured Spinal Cord Neurons through implantable polymer bridges. 2007-2010. €305,694.

Health Research Board: PI Genetic Engineering of Vein Grafts to prevent Restenosis. 2007-2010. €273,000.

European Union Framework 7 PurStem EU FP7: Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterisation. 2008-2011. €1,111,960

Science Foundation Ireland: Systems Biology Ireland: A systems biology approach towards understanding mesenchymal stem cell migration. 2008-2012. €2,930,854.

Professional and Personal Interests: 

Professional memberships:

  • American College of Physicians
  • American Medical Association
  • American Diabetes Association
  • American Association for the Advancement of Science
  • American Federation of Clinical Research
  • Royal College of Physicians of Ireland
  • Arteriosclerosis Council of the American Heart Association
  • American Society of Gene Therapy
  • Irish Heart Foundation
  • Editorial Board of Endocrine Practice and the Journal of Translational Medicine
  • Editor-in-Chief of Stem Cell Research & Therapy - http://www.stemcellres.com
  • North American Vascular Biology Association
  • Scientific Editorial Board of Human Gene Therapy
     

 

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