Prof. John Laffey
Professor of Anaesthesia and Intensive Care Medicine, NUI GalwayProfessor of Anaesthesia, NUI Galway
Development of therapeutic strategies for acute lung injury and ARDS
Project 1 Title:
Hypercapnic Acidosis and Ventilator Induced Lung Injury: Developing strategies to minimize injury and facilitate Repair
Project 2 Title:
Modulation of NF-kB to enhance the safety and therapeutic potential of Hypercapnic Acidosis in Sepsis induced ARDS’
Project 3 Title:
Determining the role of attenuation of oxidant mediated injury in mediating the effects of Hypercapnic acidosis in acute lung injury.
2001 – 2002
HRB Postdoctoral Fellowship, Department of Physiology, University College Dublin
2001
Doctor of Medicine (MD) Degree, NUI Galway
2000
Certificate of Specialist Training in Anaesthesia, College of Anaesthetists
2000
Young Investigator Award, American Society of Critical Care Anesthesiologists
1999 – 2000
Research Fellowship in Lung Biology, Hospital for Sick Children, University of Toronto
(1) Costello J, Higgins B, Contreras M, Ni Chonghaile M, Hassett P, O’ Toole D, Laffey JG. Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med 2009 (in press).
(2) Nichol A, O’ Croinin D, Howell K, Naughton F, O’Brien S, Boylan J, O’Connor CM, O’Toole D, Laffey JG, McLoughlin P. Infection induced lung injury is worsened following renal buffering of hypercapnic acidosis Crit Care Med 2009 (in press).
(3) MacLoughin R, Higgins B, Laffey JG, O’Brien T. Optimised aerosol delivery in an in vitro model of a mechanically ventilated rodent. J Aerosol Med 2009 (in press).
(4) Ni Chonghaile M, Higgins B, Costello J, Laffey JG. Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia. Anesthesiology 2008; 109(5):837-848
(5) Ni Chonghaile M, Higgins B, Costello J, Laffey JG. Hypercapnic acidosis attenuates the severity of severe pulmonary sepsis by a neutrophil independent mechanism. Critical Care Medicine 2008 Dec;36(12):3135-44.
(6) Heraty KB, Laffey JG, Quinlan HJ. Fluid dynamics of gas exchange in high frequency oscillatory ventilation: in vitro investigations in idealised and anatomically realistic airway bifurcation models. Annals of Biomedical Engineering 2008 Nov;36(11):1856-69. Epub 2008 Sep 11 [PMID: 18785010]
(7) O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P. Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury* Crit Care Med. 2008 Jul;36(7):2128-35. PMID: 18552698
(8) Kennedy M, Higgins B Laffey JG. Hypertonic Saline reduces inflammation and enhances the resolution of Oleic Acid induced Acute Lung Injury. BMC Pulmonary Medicine 2008 Jul 8;8(1):9. [PMID: 18611275]
(9) O' Croinin DF, Hopkins NO, Moore MM, Boylan JF, McLoughlin P, Laffey JG. Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury. Crit Care Med. 2005 Nov;33(11):2606-2612
(10) Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF, McLoughlin P. Hypercapnic Acidosis Attenuates Endotoxin-induced Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine 2004 Jan 1;169(1):46-56.
(11) Laffey JG, Jankov R, Engelberts D, Tanswell AK, Post M, Lindsay T, Mullen JB, Romaschin A, Stephens D, McKerlie C, Kavanagh BP. Effects of Therapeutic Hypercapnia on Mesenteric Ischemia – Reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 2003 Dec 1;168(11):1383-90.
(12) Laffey JG, Kavanagh BP. Mechanisms of Disease: Hypocapnia. The New England Journal of Medicine 2002; 347 (1): 43-53.
(13) Laffey JG, Kavanagh, BP. Carbon dioxide and the critically ill: too little of a good thing? Lancet 1999 Oct 9; 354(9136): 1283 – 1286.
John Laffey' s major research interest is in the study of the pathophysiology of, and the development of therapeutic strategies for, acute lung injury and ARDS, a devastating disease process affecting seriously ill adults and children. His clinical interests include intensive care medicine, obstetric, paediatric and vascular anaesthesia, and acute pain medicine.
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