Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Prof. Frank Barry

Phone: 
+353 91 495108
frank.barry@nuigalway.ie

Scientific Director of REMEDI

The therapeutic application of adult stem cells, especially mesenchymal stem cells (MSCs) from bone marrow.

Researcher in

Research Project Area: 

The therapeutic application of adult stem cells, especially mesenchymal stem cells (MSCs) from bone marrow. For 10 years he directed a series of research programmes focusing on the isolation and characterization of adult stem cells, and on the development of methods for their delivery in a variety of clinical indications. This has included cardiovascular and arthritic diseases. He has developed approaches for the use of MSCs for the delivery of specific therapeutic genes, for example in rheumatoid arthritis. He has also explored the phenotype of bone marrow-derived stem cells in patients with advanced osteoarthritis. These studies indicated that patients have functionally depleted reservoirs of stem cells in the marrow. These data suggest that stem cells may be a component of the diseases process and at the least will influence future strategies in cell-based repair for these patients.   In addition he has an interest in proteomics and mass spectrometry for the identification of surface molecules on cells.

Topics covered include the following: 

• Biology of adult stem cells
• Tissue engineering
• Cell transplantation protocols
• Immunology of allogeneic cell transplantation
• Gene therapy
• Cell-based gene delivery
• Regulation of differentiation
• Mechanisms of engraftment and homing of transplanted stem cells
• Stem cell plasticity
 

Positions Held: 

2009 - Present
Director, National Centre of Biomedical Engineering Science(NCBES), NUI Galway

2005 - Present
Professor of Cellular Biology, NUI Galway

2004 - Present
Scientific Director, Regenerative Medicine Institute, NUI Galway

1998 – 2004
Director of Arthritis Research, Osiris Therapeutics Inc., Baltimore, MD, USA.

1997 - 1998
Associate Director, Cartilage Research and Analytical Biochemistry, Osiris Therapeutics Inc., Baltimore, MD, USA

1994 - 1997
Senior Research Scientist and Manager, Biomatrix Development, Osiris Therapeutics Inc. Cleveland OH and Baltimore, MD, USA.

1992 - 1994
Assistant Professor, Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida

1992 - 1994
Research Fellow, Shriners Hospital for Children, Tampa, Florida, USA.

1990 - 1992
Research Scientist, Shriners Hospital for Children, Tampa, Florida, USA.

1989 - 1989
Visiting Scientist, Kennedy Institute of Rheumatology, London, UK.

1985 - 1989
College Lecturer, Biochemistry Department, University College Cork, Ireland.

1984 - 1985
Research Scientist, Clinical Diagnostics Division, Biocon Biochemicals Ltd., Cork, Ireland.

1983 - 1984
Post-doctoral Fellow, Kennedy Institute of Rheumatology, London, UK

1980 - 1983
Ph.D in Biochemistry, UCC

Awards & Honours: 

European Union FP7 Health Sciences Focused Project: PurStem: Manufacturing, Process Development and Characterization of Bone Marrow-Derived Stem Cells (coordonator Frank Barry). €2.75m. 2008

Smith & Nephew and Industrial Development Agency jointly funded research Award: CARA (Cellular Arthroplasty for Regenerationin Arthritis. €6.25m. 2007

Enterprise Ireland C+ Award: Stem Cell Technology and Therapy. €200,000. 2007

Enterprise Ireland Feasability Award: Stem Cell Banking and Technology. €25,000. 2006

Infrastructure Award. Health Research Board. Laser Microdissection System. €129,000. 2005

Supplemental Equipment Award, Science Foundation Ireland. High Speed Cell Sorter. €465,000. 2005

Modulation of wound response and control of stem cell maintenance and migration in the injured host. Defense Advanced Research Projects Agency, US Department of Defense. $2m (Co-applicant with M Pittenger) 2002-2004

Centre for Science and Engineering Technology award for the Regenerative Medicine Institute, NUI Galway. Science Foundation Ireland. €15m (Co-applicant with T. O’Brien) 2004-2008

Supplemental Equipment Award, Science Foundation Ireland. High Speed Cell Sorter. €465,000. 2005

Selected Publications: 

O'Sullivan J, D'Arcy S, Barry FP, Murphy JM, Coleman CM. Mesenchymal chondroprogenitor cell origin and therapeutic potential. Stem Cell Res Ther. 2011 Feb 18;2(1):8. [Epub ahead of print]

PMID:21371355Little CB, Smith MM, Cake MA, Read RA, Murphy MJ, Barry FP. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S80-92.

Moloney TC, Rooney GE, Barry FP, Howard L, Dowd E. Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain.  Brain Res. 2010 Nov 4;1359:33-43. Epub 2010 Aug 21.

Advances in mesenchymal stem cell-mediated gene therapy for cancer.  Dwyer RM, Khan S, Barry FP, O'Brien T, Kerin MJ. Stem Cell Res Ther. 2010 Aug 9;1(3):25.

O'Shea CA, Hynes SO, Shaw G, Coen BA, Hynes AC, McMahon J, Murphy M, Barry F, O'Brien T. Bolus Delivery of Mesenchymal Stem Cells to Injured Vasculature in the Rabbit Carotid Artery Produces a Dysfunctional Endothelium.
Tissue Eng Part A. 2010 Feb 24.(4.7)
 

Coleman CM, Curtin C, Barry FP, O'Flatharta C, Murphy JM.Mesenchymal stem cells and osteoarthritis: remedy or accomplice?  Hum Gene Ther. 2010 Oct;21(10):1239-50.

Moloney TC, Dockery P, Windebank AJ, Barry FP, Howard L, Dowd E.  Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain.  Neurorehabil Neural Repair. 2010 Sep;24(7):645-56. Epub 2010 Apr 8.

Hoare M, Greiser U, Schu S, Mashayekhi K, Aydogan E, Murphy M, Barry F, Ritter T, O'Brien T. Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides.
J Gene Med. 2010 Feb;12(2):207-18. (3.1)
 

Martin FT, Dwyer RM, Kelly J, Khan S, Murphy JM, Curran C, Miller N, Hennessy E, Dockery P, Barry FP, O’Brien T, Kerin MJ.
Potential Role of Mesenchymal Stem Cells (MSCs) in the Breast Tumour Microenvironment: Stimulation of Epithelial to Mesenchymal Transition (EMT).
Breast Cancer Res Treat. 2010 Jan 20. [Epub ahead of print] (5.6). 
 

O'Cearbhaill ED, Murphy M, Barry F, McHugh PE, Barron V.
Behavior of Human Mesenchymal Stem Cells in Fibrin-Based Vascular Tissue Engineering Constructs.
Ann Biomed Eng. 2010 Jan 14. [Epub ahead of print] (2.6)
 

 Kealy B, Liew A, McMahon JM, Ritter T, O'Doherty A, Hoare M, Greiser U, Vaughan EE, Maenz M, O'Shea C, Barry F, O'Brien. T.Comparison of Viral and Nonviral Vectors for Gene Transfer to Human Endothelial Progenitor Cells. Tissue Eng Part C Methods. 2009 Jan 20 (4.7)

K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP.  Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High) forkhead box P3(+) regulatory T cells. English, Clin Exp Immunol 156(1):149-160 (2.9)

Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Fluegel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry F. Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation into the Contused Spinal Cord without Differentiating into Neural Cells.
Tissue Eng Part A. 2009 Mar 31. [Epub ahead of print] (4.7)
 

Rooney GE, Howard L, O'Brien T, Windebank AJ, Barry FP. Elevation of cAMP in mesenchymal stem cells transiently upregulates neural markers rather than inducing neural differentiation. Stem Cells Dev. 2009 Apr;18(3):387-98 (3.3)

O'Brien T, Barry FP.Stem cell therapy and regenerative medicine. Mayo Clin Proc. 2009 Oct;84(10):859-61

Molloy AP, Martin FT, Dwyer RM, Griffin TP, Murphy M, Barry FP, O'Brien T, Kerin MJ.
Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells.
Int J Cancer. 2009 Jan 15;124(2):326-32 (4.7)
 

McMahon SS, Albermann S, Garcia Y, Hynes J, Dockery P, Rooney GE, Shaw G, O’Brien T, Windebank AJ, Allsopp TE, Barry FP.  Engraftment, Migration and Differentiation of Neural Stem Cells in Contused Rat Spinal Cord
Neuroscience (3.6)
 

Molloy AP, Martin FT, Dwyer RM, Griffin TP, Murphy M, Barry FP, O'Brien T, Kerin MJ.  Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells. Int J Cancer. 2008 Nov 11. [Epub ahead of print] PMID: 19003962

Sharif F, Hynes SO, Cooney R, Howard L, McMahon J, Daly K, Crowley J, Barry F, O'Brien T. Gene-eluting stents: adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis. Mol Ther. 2008 Oct;16(10):1674-80. Epub 2008 Aug 19. PMID: 18714308

Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O'Brien T, Howard L, Windebank AJ, Barry FP. Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Eng Part A. 2008 May;14(5):681-90. PMID: 18402551

Rooney GE, Howard L, O'Brien T, Windebank AJ, Barry FP. Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers rather than Inducing Neural Differentiation. Stem Cells Dev. 2008 Jun 13. [Epub ahead of print] PMID: 18554089

Mohr A, Lyons M, Deedigan L, Harte T, Shaw G, Howard L, Barry F, O'Brien T, Zwacka R. Mesenchymal Stem Cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model. J Cell Mol Med. 2008 Mar 28. [Epub ahead of print PMID: 18373740

Mylotte LA, Duffy AM, Murphy M, O'Brien T, Samali A, Barry F, Szegezdi E. Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment. Stem Cells. 2008 May;26(5):1325-36. Epub 2008 Feb 28. PMID: 18308942

O'Cearbhaill ED, Punchard MA, Murphy M, Barry FP, McHugh PE, Barron V. Response of mesenchymal stem cells to the biomechanical environment of the endothelium on a flexible tubular silicone substrate. Biomaterials. 2008 (11):1610-9.

Sen S, Conroy S, Hynes SO, McMahon J, O'Doherty A, Bartlett JS, Akhtar Y, Adegbola T, Connolly CE, Sultan S, Barry F, Katusic ZS, O'Brien T. Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5. J Gene Med. 2008 Feb;10(2):143-51.

English K, Barry FP, Mahon BP. Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation. Immunol Lett. 2008 Jan 15;115(1):50-8.

Flynn A, Barry F, O'Brien T. UC blood-derived mesenchymal stromal cells: an overview. Cytotherapy. 2007;9(8):717-26.

Liew A, McDermott JH, Barry F, O'brien T. Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box? Diabetes Obes Metab. 2007 Sep 6

English, K, Barry FP, Field-Corbett C, Mahon B.(2007) IFN- and TNF- differentially regulate immunomodulation by murine mesenchymal stem cells. Immunology Letters. 110:91-100

Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O'Brien T, Kerin MJ. Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin Cancer Res. 2007 Sep 1;13(17):5020-7

McMahon, J.M., Conroy, S., Lyons, M., Greiser, U., O’Shea, C., Strappe, P., Howard, L., Murphy, M., Barry, F. & O’Brien, T. (2006) Gene transfer into rat mesenchymal stem cells: a comparative study of viral and non-viral vectors Stem Cells Dev 15:87-96

Liew A, Barry F, O'Brien T. (2006) Endothelial progenitor cells: diagnostic and therapeutic considerations. Bioessays. 28, 261-270.

 Barry FP, Murphy JM, O Brien T and Mahon BP (2005) Mesenchymal Stem Cell Transplantation for Tissue Repair. Seminars in Plastic Surgery. 19, 229 - 239

Ryan J, Barry FP, Murphy JM, Mahon BP (2005). Mesenchymal stem cells avoid allogeneic rejection: a combination of hypoimmunogenicity and immune suppression. J Inflamm (Lond) 2:8.

Barry FP, Murphy JM (2004) Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 36, 568-584.

 Barry FP (2004) Mesenchymal stem cells in joint repair in Tissue Engineering in Musculoskeletal Clinical Practice (ed. Sandell LJ and Grodzinksy, AJ) Amer Acad Orthop Surg, Rosemont IL

Barry FP, Murphy JM. (2004) Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 36, 568-584.

Murphy JM, Fink DJ, Hunziker EB, Barry FP (2003) Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 48, 3464-3474.

Barry FP (2003) Biology and clinical applications of mesenchymal stem cells. Birth Defects Res Part C Embryo Today. 69, 250-256.

Barry F (2003). Mesenchymal Stem Cell Therapy in Joint Disease. Novartis Foundation Symposium. 249, 86-96.

Kavalkovich, KW, Boynton, RE, Murphy, JM, Barry, F (2002). Chondrogenic Differentiation of Human Mesenchymal Stem Cells within an Alginate Layer Culture System. In Vitro Cell Dev Biol Anim 38, 457-466.

Murphy, JM, Dixon, K, Beck, Fabian, DF, Feldman, and Barry, FP (2002). Reduced Chondrogenic and Adipogenic Activity of Mesenchymal Stem Cells from Patients with Advanced Osteoarthritis. Arthritis Rheumatism 46, 704-713.

Devine SM, Peter S, Martin BJ, Barry F, McIntosh KR (2001). Mesenchymal stem cells: stealth and suppression. Cancer J 2, 76-82.

Barry, F, Boynton, R, and Zaia, J (2001). The SH-3 and SH-4 Monoclonal Antibodies Recognize Distinct Epitopes on CD73 from Human Mesenchymal Stem Cells. Biochem Biophys Res Commun 289, 519-524.

68 Malaviya P, Butler DL, Boivin GP, Smith FNL, Barry FP, Murphy JM and Vogel, KG (2000). An in vivo model for load-modulated remodeling in the rabbit flexor tendon. J Orthopaedic Res 18, 116-125.

Book Chapters

Barry FP (2004) Mesenchymal stem cells in joint repair in Tissue Engineering in Musculoskeletal Clinical Practice (ed. Sandell LJ and Grodzinksy, AJ) Amer Acad Orthop Surg, Rosemont IL

Barry, FP. (2003) Mesenchymal Stem Cell Therapy in Cartilage Repair in Tissue Engineering in Musculoskeletal Clinical Practice (Sandell, LJ, ed.) American Academy of Orthopaedic Surgeons

Professional and Personal Interests: 

Professional Memberships

Tissue Engineering Society International
Orthopaedic Research Society (ORS)
International Cartilage Repair Society (ICRS)
American Association for the Advancement of Science
Biochemical Society
Association of Biomolecular Resource Facilities
International Society for Cell Therapy (ISCT)
International Society for Stem Cell Research
Orthoarthritis Research Society International (OARSI)
 

Referee of Journals

Biochimica Biophysica Acta
Journal of Orthopaedic Research
Tissue Engineering
Journal of Histochemistry and Cytochemistry
Journal of Biological Chemistry
Nature Biotechnology
Arthritis and Rheumatism
Osteoarthritis and Cartilage
 

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