Cell stress and resultant cell death can lead to loss of tissue and organ function and plays a major part in many diseases. Oxidative stress (OS) is implicated in conditions such as atherosclerosis, cancer, macular degeneration and various neurodegenerative disorders such as Parkinson’s, Huntington’s and Alzheimer’s. OS occurs when there is a malfunction in the cell’s ability to neutralise free radicals; this results in an insufficient supply of antioxidants and may result in a net increase in the amount of free radicals present in the local cellular environment. This can lead to irreversible cell damage, which may result in mutagenic effects and tissue injury. We are using lentiviral vectors to transduce mesenchymal stem cells to promote survival under both oxidative and hypoxic conditions.