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Dr. Sean Hynes

sean.hynes@nuigalway.ie

Sean's research aims to improve the outcome of vascular interventions in particular percutaneous cardiac interventions such as angioplasty and/or stenting

Researcher in

Research Project Area: 

Neointima proliferation occurs informs in blood vessels following vascular interventions such as stent deployment and is termed in-stent restenosis. This neointima may have the effect of impairing blood flow and causing subsequent intervention failure. The aim of my research is to improve the outcome of vascular interventions in particular percutaneous cardiac interventions such as angioplasty and/or stenting. We are attempting to prevent post-intervention failure which can occur due to in-stent restenosis using various gene therapy and stem cell approaches to enhance normal vessel wall regeneration.

Positions Held: 

2005-present
Postdoctoral Researcher
REMEDI
Cardiovascular Gene and Cell Therapy

2008-Present
Surgical Intern Galway University Hospital

2003-2008
Medical Degree awarded (MB BCh BAO)
School of Medicine, National University of Ireland, Galway

2002-2003
Postdoctoral Fellow
Mayo Clinic, MN, USA
Cardiovascular Gene Therapy

2000-2002
Postdoctoral Researcher
Lund University, Sweden Microbial Diagnostics and Toxicology

1992-2000
Science degree and doctorate awarded (BSc, PhD)
Dept. of Microbiology, National University of Ireland, Galway Microbial Glycomics and Toxicology
 

Awards & Honours: 

2007
Commercialisation Fund for Technology Development, from Enterprise Ireland, for development of coronary stent technology, €500,000.

2004 & 2005
University Scholar awards in Undergraduate Medicine

2004
Research Gold Medal from the Faculty of Medicine and Health Sciences Research Meeting, National University of Ireland, Galway, 2004.

Selected Publications: 

Hynes SO, McCabe C, O'Brien T.  β cell protection by inhibition of iNOS through lentiviral vector-based strategies. Methods Mol Biol. 2011;704:153-68.
 

O'Shea CA, Hynes SO, Shaw G, Coen BA, Hynes AC, McMahon J, Murphy M, Barry F, O'Brien T. Bolus delivery of mesenchymal stem cells to injured vasculature in the rabbit carotid artery produces a dysfunctional endothelium. Tissue Eng Part A. 2010 May;16(5):1657-65.

Sen S, Conroy S, Hynes SO, McMahon J, O’Doherty A, Bartlett JS, Akhtar Y, Adegbola T, Connolly CE, Sultan S, Barry F, Katusic Z, O’Brien T. Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5. Journal of Gene Medicine 2008. 10(2):143-151.

Gaffney MM, Hynes SO, Barry F, O’Brien T. Cardiovascular gene therapy: Current Status and Therapeuic Potential. British Journal of Pharmacology 2007. 152(2):175-188.

Cooney R, Hynes SO, Sharif F, Howard L, O’Brien T. Effect of delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury. Gene Therapy 2007.14(5):396-404.

Cooney R, Hynes SO, Duffy AM, Sharif F, O'Brien T. Adenoviral- mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation. Journal of Vascular Research 2006. 43(5):462-72.

Sharif F, Hynes SO, McMahon J, Cooney R, Conroy S, Dockery P, Duffy G, Daly, K, Crowley J, Bartlett JS, O'Brien T. Gene-eluting stents: comparison of adenoviral and adeno- associated viral gene delivery to the blood vessel wall in vivo. Human Gene Therapy 2006. 17(7):741-50.

Shariff F, Hynes SO, McMahon, J, et al. Prolonged adenovirus and adeno-associated virusmediated gene delivery to rabbit iliac arteries using gene-eluting stents: A direct comparison. Journal of the American College of Cardiology 2006, February
47 (4): 304A-305A Suppl. A

Oral Presentations
Hynes SO, Sharif F, Cooney RJ, O’Brien T. Preclinical potential for prevention of in-stent restenosis using gene therapy strategies.
Presentation at the Medical Faculty Research Meeting, National University of Ireland, Galway. 2007.O’Shea C, Hynes SO, Shaw G, Barry F, Murphy M, O’Brien T. Mesenchymal stem cells impair vasomotor function in a denuded rabbit carotid artery. 11th American Society for Gene Therapy Meeting, Boston 2008, June

Poster Presentations
O’Shea C, Hynes SO, Strappe P, Barry F, O’Brien T. Lentiviral-Mediated Gene Delivery to vascular cells in vitro and in vivo. 11th American Society for Gene Therapy Meeting, Boston 2008, June

O’Shea C, Hynes SO, Barry F, O’Brien T. Engraftment of MSCs into injured vasculature a potential therapeutic application. XIVth European Society for Gene Therapy meeting, Athens. 2006, November

Hynes SO, Cooney RJ, Sharif F, O’Brien T. The effect of gene delivery of eNOS and iNOS on neointimal hyperplasia and endothelial regeneration following catheter-mediated injury in the rabbit
carotid artery. XIVth European Society for Gene Therapy meeting, Athens 2006, November

Cooney RJ, Hynes SO, Sharif F, O'Brien T. NOS Isoforms, Intimal Hyperplasia and Endothelial Regeneration after Balloon Injury. 9th American Society for Gene Therapy meeting, Baltimore 2006, June

Hynes N, Hynes SO, Sultan S. A novel model for carotid artery injury in a New Zaland White rabbit. Irish Angiology Meeting, Dublin 2006, October

In addition to 29 original research papers and 65 abstracts from previous research
 

Professional and Personal Interests: 

I have played tag rugby for NCBES/REMEDI as well as soccer and gaelic football for both NCBES/REMEDI and the Galway hospitals. I have previously played/coached with Moycullen basketball club.

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