Dr. Sabine Schu
Postdoctoral Researcher sabine.schu@nuigalway.ieSabine's research focuses on analysing the immunomodulatory properties of mesenchymal stem cells.
Researcher in
Mesenchymal stem cells (MSCs) are a fascinating component of the microenvironment in the bone marrow and other tissues. They have been shown to differentiate into several different types of tissue and exhibit remarkable immunomodulatory properties. MSCs have the potential to effectively treat immune-mediated diseases like graft-versus-host disease or allogeneic rejection.
The aim of my project is to investigate how MSCs interact with allogeneic immune cells and further our understanding of the mechanisms underlying the immunomodulatory effects of MSCs.
2005-present
Postdoctoral resercher
REMEDI
Analysing the immunomodulatory properties of mesenchymal stem cells
2001-2005
PhD student
Institute of Medical Immunology, Humboldt-Universität zu Berlin, Charité University Medicine, Berlin, Germany
Modification of primary endothelial cells with antiapoptotic genes using lentiviral gene transfer to improve their protection against rejection after allogeneic transplantation
Oral Presentations
Down-regulation of MHC class I protects mesenchymal stem cells against T-cell mediated cytotoxicity in an inflammatory surrounding 3rd World Congress on Regenerative Medicine (WCRM), Leipzig, Germany. Oct 2007
Poster Presentations
MHC class I dependent lysis of allogenic MSCs by cytotoxic T cells is reduced in Ad-Ox18sc 'intrabody' expressing MSCs. 2nd Conference of the Irish Society of Gene & Cell Therapy, Cork, Ireland
May 2008
Down-regulation of MHC class I on mesenchymal stem cells protects them from T-cell mediated cytotoxicity in an inflammatory surrounding Inaugural Conference of the Irish Society of Gene & Cell Therapy, Galway, Ireland, May 2007