Roisin investigates the potential of human MSCs as vectors for therapeutic gene delivery to breast tumor tissue
Researcher in
- Tumour specific Migration of MSCs
- Breast Tumour Microenvironment
- Chemokines and Cancer
- MSCs in the pre-metastatic niche
- Breast Cancer-Bone Metastases
2005-present
Research Fellow
Dept of Surgery and REMEDI, NUIG
Investigation of the potential of human Mesenchymal Stem Cells (hMSC) as vectors for therapeutic gene delivery to breast tumor tissue
2002-2005
Post-doctoral Researcher
Mayo Clinic, Rochester, Minnesota, USA
Adenovirus–mediated transcriptional targeting of Sodium Iodide Symporter (NIS) expression to cancer using tumor specific promoters for radioiodide imaging and therapy.
1998-2002
PhD
Dept of Medicine and Therapeutics, University College Dublin
Investigation of Iodide Uptake and Metabolism in Breast Cancer
Nov 2005
NUI Postdoctoral Fellowship in the Sciences
Nov 2007
HRB Research Project Grant
April 2008
CRI Research Project Grant
Potter SM, Dwyer RM, Curran CE, Hennessy E, Harrington KA, Griffin DG and Kerin MJ. Systemic Chemokine Levels in Breast Cancer Patients and Their Relationship with Circulating Menstrual Hormones. Breast Cancer Research and Treatment (2008) [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/18521742
Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O’Brien T and Kerin MJ. Monocyte Chemotactic Protein-1 (MCP-1) secreted by primary breast tumors stimulates migration of Mesenchymal Stem Cells (MSCs). Clinical Cancer Research (2007) 13 (17): 5020-5027
http://www.ncbi.nlm.nih.gov/pubmed/17785552
Dwyer RM, Bergert ER, Gendler SJ, O’Connor MK and Morris JC. Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors. Human Gene Therapy (2006) 17(6): 661-668.
http://www.ncbi.nlm.nih.gov/pubmed/16776574
Dwyer RM, Bergert ER, Gendler SJ, O’Connor MK and Morris JC. Sodium Iodide Symporter (NIS)-mediated Radioiodide Imaging and Therapy of Ovarian Tumor Xenografts in Mice. Gene Therapy (2006) 13(1): 60-66.
http://www.ncbi.nlm.nih.gov/pubmed/16121204
Dwyer RM, Bergert ER, Myers RM, Harvey ME, Classic KL, Marler RJ, O’Connor MK and Morris JC. A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium-Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer. Molecular Therapy (2005) 12(5): 835-841.
http://www.ncbi.nlm.nih.gov/pubmed/16054438
Dwyer RM, Bergert ER, Gendler SJ, O’Connor MK and Morris JC. In Vivo Radioiodide Imaging and Treatment of Breast Cancer Xenografts Following MUC1-driven Expression of the Sodium Iodide Symporter (NIS). Clinical Cancer Research (2005) 11(4): 1483-1489.
http://www.ncbi.nlm.nih.gov/pubmed/15746050
Smyth PPA and Dwyer RM. The Sodium Iodide Symporter and Thyroid Disease. Clinical Endocrinology (2002) 56(4):427-9.
http://www.ncbi.nlm.nih.gov/pubmed/11966734
Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EWM, O'Higgins N J and Smyth PPA. Tissue Iodine Content and Serum Mediated 125I Uptake Blocking Activity in Breast Cancer. Journal of Clinical Endocrinology and Metabolism (2000) 85: 1245-1250.
http://jcem.endojournals.org/cgi/content/full/85/3/1245