Principal Investigator Orthobiologics Group
The Biology, Mechanism of action and Use of adult stem cells for tissue regeneration in osteoarthritis.
Researcher in
The biology, mechanism of action and the use of adult stem cells for tissue regeneration in orthopaedic applications with a specific emphasis in cartilage repair and osteoarthritis. This research focuses on the isolation, characterization and differentiation of mesenchymal stem cells, the effects of ageing and disease on stem cells, and the development of pertinent models and therapeutic modalities for mesenchymal stem cells in tissue regeneration.
Biology of vascular derived stem cells in atherosclerosis
Cardiomyogenic differentiation of adult stem cells: effect of electroactive particles (collaboration with Valerie Barron, NCBES)
2006-present: Lecturer in Regenerative Medicine Dept of Medicine
2004-present: Snr. Researcher and Director of Toxicology REMEDI
2001-2004: Senior Manager, Arthritis Research Osiris Therapeutics Inc., Baltimore, MD, USA
1999-2001: Manager, Arthritis Research
1995-1999: Research Scientist, Cartilage Res. and Analytical Biochemistry
1991-1994: Postdoctoral fellow Department of Obstetrics and Gynaecology, University of South Florida, Tampa, Florida, USA Etiology of smooth muscle cell tumours
1990-1991: Postdoctoral fellow Department of Ophthalmology, University of South Florida, Tampa, Florida, USA The early events in the formation of connective tissue during wound repair
1988-1989: Research fellow Department of Medicine, University College Cork, Ireland Renin-angiotensin system in diabetes
1986-1988: Postdoctoral fellow Dept of Food Chemistry, University College Cork, Ireland Isolation and characterization of milk proteins
1983-1986: Research Biochemist Research Biochemist, Clinical Diagnostics Division, Flemming GmbH, Co. Clare, Ireland
Development of clinical diagnostic reagents
Mooney E, Dockery P, Greiser U, Murphy M*, Barron V*. Carbon Nanotubes and Mesenchymal Stem Cells: Biocompatibility, Proliferation and Differentiation. Nano Lett. 2008 Jul 12. [Epub ahead of print]
Dwyer, RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Murphy JM, Barry FP, O’Brien T and Kerin MJ. Monocyte Chemotactic Protein-1 (MCP-1) secreted by primary breast tumors stimulates migration of Mesenchymal Stem Cells (MSCs). Clinical Cancer Research (2007) 13 (17): 5020-5027.
Barry FP, Murphy JM, English K, Mahon BP (2005). Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. Stem Cells Dev 14:252-65.
Barry FP, Murphy JM (2004). Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 36:568-84.
Murphy JM, Fink DJ, Hunziker EB, Barry FP (2003). Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 48:3464-74.
Murphy JM, Dixon K, Beck S Fabian DF, Feldman A, Barry FP (2002). Reduced chondrogenic and adipogenic activity of MSCs from patients with advanced osteoarthritis. Arthritis Rheum 46:704-713.
Barry F, Boynton R, Murphy M and Zaia J (2001). The SH-3 and SH-4 Antibodies Recognize Distinct Epitopes on CD73 from Human Mesenchymal Stem Cells. Biochem. Biophys. Res. Commun. 289:519-24
Barry F, Boynton RE, Liu B and Murphy JM (2001). Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp. Cell Res. 268:189-200
Barry FP, Boynton RE, Haynesworth S, Murphy JM and Zaia J (1999). The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem. Biophys. Res. Commun. 265:134-139.
Murphy JM, Heinegård D, McIntosh A, Sterchi D and Barry FP (1999). Distribution of cartilage molecules in the developing mouse joint: articular chondrocytes constitute a unique sub-set of cells. Matrix Biol. 18:487-497.
MacKay AM, Beck SC, Murphy JM, Barry FP, Chichester CO and Pittenger MF (1998). Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 4:415-428.