Kaveh Mashayekhi
Senior Research Fellow kaveh.mashayekhi@nuigalway.ieBioinformatics, data analysis, mining and interpretation of high throughput genomics and proteomics data
Researcher in
Bioinformatics, data analysis, mining and interpretation of high throughput genomics and proteomics data
• Using genomic and proteomics data in clinical diagnostics of cancer, stem cells and identification of key disease markers for their treatment and prevention.
• Data Reliability and Experimental Design. Statistical design and analysis, quantitative microarray analysis, quality control and optimization, algorithms, methods for gene expression and data analysis and integration with proteomics data.
• Data Normalization and Statistical Evaluation. Inferential, non-parametric statistics, universal calibration standard, application of normalization methods and experimental validation, application of bistatistical and bioinformatics methods to gene and protein expression analysis and standards for microarray data representation and annotation.
• Data Standardization, implementing standardize annotation of data and validating evaluation of microarray results in course of bioinformatics studies.
• Analysis and interpretation of gene and protein expression data, from hybridised based methods e.g. micro-, and macro arrays or RT-PCR, sequence based methods such as EST or SAGE.
• Understanding mechanisms of transcriptional regulation and deciphering corresponding gene networks by combining gene expression studies with regulatory sequence analysis of the human genome draft sequence.
• System biology combinatorial approach to understanding various biological phenomena (disease, development etc.) by combining information from gene and protein profiling Studies with SNPs/regulatory sequence data, clinical information, biological pathway knowledge etc.
Nov 2007-present
Senior Research Fellow
REMEDI
Stem Cell BIO-INFORMITCS Research
Nov 2006 – Nov 2007
Guest Professor
Department of Microbiology, National University of Ireland, Galway, Heading Functional Genomics, Proteomics and Bioinformatics aspect of a European Union Transfer of Knowledge Project, Gut and Microbe Interaction During Infection (GAMIDI). Infectious Diseases, Microbe and Human Interaction.
Sep 2005- Nov 2006
Guest Professor, Genomics and Bioinformatics Unit Leader Alexander Fleming Biomedical Science Research Center, Institute of Molecular Biology and Genetics, Al. Fleming, Athens, Greece
Jan 2000 – Aug 2005
Principal Investigator and Co-Director
Karolinska Institutet Microarray Core Facility
Karolinska Institutet, Center for Genomics and bioinformatics, Stockholm, Sweden
Jan 2002 – Aug 2005
Principal Investigator and Group Leader
Royal Institute of Technology, KTH Royal Institute of Technology, KTH. Institute for Astronomy, Astrophysics and Biotechnology, Genome center, Stockholm, Sweden.
1994 – 2000
Assistant Professor
Center for International Development and Environmental Research (ZEU) and Research Centre for BioSystems and Nutrition (IFZ), Justus Liebig University, Giessen, Germany
1988-2000
IT & Marketing coordinator (Freelancer)
Vittorio Klostermann Scientific Publishing, Frankfurt, Germany IT & Marketing
1999
On the recommendation of German National Organization for Higher Education and Culture award of the title of Doctor of Science
• Gene expression profiling reveals defects in genes regulating T cell differentiation and effector pathways in T cells in patients with CLL . Kiaii S, Mashayekhi K, Choudhury R, Mellstedt H. Haematology, 92(2):33, 2007.
• Bioinformatics Analysis of AcidRegulated Genes of the Gastroduodenal Pathogen Helicobacter pylori. Kaveh Mashayekhi, Sergey Ustinov, Anthony P. Moran. Department of Microbiology, School of Natural Sciences, National University of Ireland, Galway; National Centre for Biomedical Engineering Science, National University of Ireland, Galway. SGM:40, 2008.
• Gene Expression Profiling of Peripheral Blood T Cells in Patients with Indolent B-CELL Chronic Lymphocytic Leukemia (B-CLL). K. Kiaii, A. Österborg, A. Moshfegh,A., Mashayekhi K. Choudhury, H. Mellstedt. Karolinska Institutet.haematologica, the hematology journal, ISSN 0390-6078,Vol.92:94, 2007.
• Activity of the neurogenic protein NEURALIZED (NEUR) is required for learning and long term memory formation. FENS, vol.3: 128-135, 2006. Skoulakis E. M. C., Pavlopoulos E., Franco M. & Mashayekhi K.
• Slow Genetic Divergence of Helicobacter pylori Strains during Long-Term Colonization. Annelie Lundin, Britta Björkholm, Ilya Kupershmidt, Kaveh Mashayekhi, Magnus Unemo, Peter Nilsson, Dan I. Andersson, and Lars Engstrand. 2005 August; 73(8): 4818–4822.
• 24 Mutational analysis and gene expression profiling in malignant melanoma: implications for therapy. 25 Update of EORTC melanoma trials. Final results of the EORTC melanoma group trials: EORTC 18951 in stage IV and EORTC 18952 in stage IIB-III. Melanoma Research. 14(4):A11-A12, August 2004. Hansson, J. Huang, F. Mashyekhi, K. Omholt, K. Jovanovic, B. Sakko, A. J. Egyhazi, S. Frostvik, M. Shaw, P. Ringborg, U.