Dr. Cynthia Coleman
Senior Investigator, Orthobiologics GroupCynthia investigates the application of adult human bone marrow derived mesenchymal stem cells to treat osteoarthritis. The aim of her ongoing research is to assess the combination of mesenchymal stem cells (MSCs) and growth/differentiation factor 5 (GDF-5) as a potential therapeutic for arthritis, specifically focusing on the deposition of extracellular matrix proteins.
Researcher in
We are interested in the application of human bone marrow derived mesenchymal stem cells to treat osteoarthritis
Adipose derived stromal cells for osteoarthritis (ADIPOA) Utilization of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization (PurStem)
Cellular Arthroplasty for Regeneration in Arthritis (CARA) Enhancement of mesenchymal stem cell chondrogenesis with the addition of growth/differentiation factor 5
2010 - Present Honorary Research Lecturer in Orthobioloigcs, National University of Ireland, Galway
2007 - Present
Senior Scientist, Orthobiologics
REMEDI, NUI Galway
The application of adult human bone marrow derived mesenchymal stem cells to treat osteoarthritis
2004 - 2007
Senior Scientist
Johnson & Johnson Regenerative Therapeutics
Providing proof of principle and efficacy data generated in vitro and in vivo data for early stage projects in cartilage repair
2002 - 2004
Post-Doctoral Fellow
National Institutes of Health, National Institute of Arthritis. Musculoskeletal and Skin Diseases Role of growth factors in regulating chondrocyte extracellular matrix composition
1997 - 2002
Ph.D Student
Thomas Jefferson University, Philadelphia, PA, USA
Student of developmental biology and teratology with specific emphasis on the function of growth factors in embryonic limb mesenchymal cell condensation and subsequent differentiation
2010 Journal of Tissue Engineering and Regenerative Medicine manuscript referee
Journal of Orthopaedic Research manuscript referee
Orthopaedic Research Society abstract referee for Biomaterials-Bioactive section
Awarded the cover photograph on Human Gene Therapy
2009 - 2010 TERMIS EU 2010 symposium coordinator
Cell Tissues Organs manuscript referee
Stem Cell Research & Therapy manuscript referee
2008 Biotechnology & Biological Sciences Research Council referee of funding applications
2008 - 2011 British Society for Matrix Biology member
2008 - 2009 Orthopaedic Research Society annual meeting chair of Bone Fracture symposium
2007 Orthopaedic Research Society annual meeting Bone Fracture abstract referee
2005 - 2011 Orthopaedic Research Society member
2008 Contributor to Faculty of 1000 Medicine reviews
2008 Chair of fracture repair scientific sessions at annual ORS meeting
2007 Reviewer of fracture repair abstracts in preparation for annual ORS meeting
2002 & 2003 National Institute of Health Post-doctoral intramural research training fellowship
2000 Sigma Xi Grant in Aid Research Award recipient
1999 Doctoral student Foerderer fellowship, Thomas Jefferson University, USA
1999 Grand prize of Teratology society student web page design contest. Reviewed in Science vol 287, p1883.
1997 & 1998 Doctoral student Foerderer fellowship, Thomas Jefferson University, USA
J. O’Sullivan, S. D’Arcy, F. P. Barry, J.M. Murphy, C.M. Coleman. Mesenchymal Chondroprogenitor Cell Origin, Isolation and Therapeutic Potential. Accepted: Stem Cell Research & Therapy, 2011.
E. Vaughan, A. Liew, K. Mashayekh, P. Dockery, J. McDermott, B. Kealy, A. Flynn, A. Duffy, C. M. Coleman, A. O’Regan, F. Barry, T. O’Brien. Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease. Accepted: Cell Transplantation, 2010.
C. M. Coleman, B.H. Scheremeta, A. T Boyce, R. M. Mauck, R. S. Tuan. 2010. Fracture Healing in GDF-5 Deficient Mice. Accepted: Clinical Orthopaedics and Related Research, 2010.
C.M. Coleman, C. Curtin, F. Barry, J.M. Murphy. 2010. Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice? Human Gene Therapy 21(10):1239-1250.
C.M. Coleman. 2008. Chicken Embryo as a Model for Regenerative Medicine. Birth Defects Research (Part C) 84:245-256.
A. Flynn, P. Sloane, C. M. Coleman, A. Stocca, L. Mylotte, J. Boucher, G. Shaw, A. Magee, C. McHale, P. Nolan, P. Nash, F. Barry, T. O’Brien. 2008 Elucidation of Engraftment and Efficacy of Syngeneic Mesenchymal Stem Cells in Rodent Myocardial Infarction. Manuscript in preparation.
A. Liew, T. Bowes, J. McDermott, B. Kealy, L. Howard, A. O’Regan, A. Flynn, C.M. Coleman, G. Avalos, F. Barry, T. O’Brien. 2008 Critical role for osteopontin in endothelial progenitor cell (EPC) mediated neovascularisation. Manuscript submitted to Arteriosclerosis, Thrombosis and Vascular Biology.
C.M. Coleman, G.A. Loredo, C.W. Lo and R.S. Tuan. 2003. Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development. Anatomical Record Part A. 275(A): 1117-1121.
C.M. Coleman and R.S. Tuan. 2003. Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation. Developmental Dynamics. 228(2): 208-216.
C.M. Coleman, G.A. Loredo, C.W. Lo and R.S. Tuan. 2003. Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development. Anatomical Record Part A. 275(A): 1117-1121.
C.M. Coleman and R.S. Tuan. 2003. Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation. Developmental Dynamics. 228(2): 208-216.
C. M. Coleman and R.S. Tuan. 2003. Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells. Mechanisms of Development. 120(7): 823-836.
L. Shum, C.M. Coleman, Y. Hatakeyama and R.S. Tuan. 2003. Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton. Birth Defects Research (Part C). 69(2): 102-122.
B. Chatterjee, R.A. Meyer, G.A. Loredo, C.M. Coleman, R.S. Tuan and C.W. Lo. 2003. BMP Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos. Cell Adhesion and Communication. 10(1): 37-50.
Research funding Secured
Science Foundation Ireland: Centre for Science, Engineering and Technology: The Regenerative Medicine Institute (REMEDI): 2004-2008. Senior Scientist investigating several cardiovascular therapies. €19 million grant obtained by Professor Tim O’Brien.
Orthopaedic Research Society Society for Developmental Biology American Society of Cell Biology Reviewer for Journal of Orthopaedic Research
