Fáilte chuig an Institiúid um Leigheas Athghiniúnach
Welcome to the Regenerative Medicine Institute (REMEDI®)

Dr. Cynthia Coleman

Senior Investigator, Orthobiologics Group
Phone: 
+353 91 495852
cynthia.coleman@nuigalway.ie

Cynthia investigates the application of adult human bone marrow derived mesenchymal stem cells to treat osteoarthritis. The aim of her ongoing research is to assess the combination of mesenchymal stem cells (MSCs) and growth/differentiation factor 5 (GDF-5) as a potential therapeutic for arthritis, specifically focusing on the deposition of extracellular matrix proteins.

Researcher in

Research Project Area: 

We are interested in the application of human bone marrow derived mesenchymal stem cells to treat osteoarthritis                         

Adipose derived stromal cells for osteoarthritis (ADIPOA)   Utilization of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization (PurStem)

Cellular Arthroplasty for Regeneration in Arthritis (CARA)  Enhancement of mesenchymal stem cell chondrogenesis with the addition of growth/differentiation factor 5

Positions Held: 

2010 - Present                                                                              Honorary Research Lecturer in Orthobioloigcs, National University of Ireland, Galway

2007 - Present
Senior Scientist, Orthobiologics 
REMEDI, NUI Galway
The application of adult human bone marrow derived mesenchymal stem cells to treat osteoarthritis

2004 - 2007
Senior Scientist
Johnson & Johnson Regenerative Therapeutics
Providing proof of principle and efficacy data generated in vitro and in vivo data for early stage projects in cartilage repair

2002 - 2004
Post-Doctoral Fellow
National Institutes of Health, National Institute of Arthritis. Musculoskeletal and Skin Diseases Role of growth factors in regulating chondrocyte extracellular matrix composition

1997 - 2002
Ph.D Student
Thomas Jefferson University, Philadelphia, PA, USA 
Student of developmental biology and teratology with specific emphasis on the function of growth factors in embryonic limb mesenchymal cell condensation and subsequent differentiation
 

Awards & Honours: 

2010  Journal of Tissue Engineering and Regenerative Medicine manuscript referee
Journal of Orthopaedic Research manuscript referee
Orthopaedic Research Society abstract referee for Biomaterials-Bioactive section
Awarded the cover photograph on Human Gene Therapy
 

2009 - 2010  TERMIS EU 2010 symposium coordinator
Cell Tissues Organs manuscript referee
Stem Cell Research & Therapy manuscript referee
 

2008  Biotechnology & Biological Sciences Research Council referee of funding applications                                                          

2008 - 2011  British Society for Matrix Biology member

2008 - 2009  Orthopaedic Research Society annual meeting chair of Bone Fracture symposium

2007  Orthopaedic Research Society annual meeting Bone Fracture abstract referee

2005 - 2011 Orthopaedic Research Society member

2008 Contributor to Faculty of 1000 Medicine reviews
2008 Chair of fracture repair scientific sessions at annual ORS meeting
2007 Reviewer of fracture repair abstracts in preparation for annual ORS meeting
2002 & 2003  National Institute of Health Post-doctoral intramural research training fellowship
2000 Sigma Xi Grant in Aid Research Award recipient
1999 Doctoral student Foerderer fellowship, Thomas Jefferson University, USA
1999 Grand prize of Teratology society student web page design contest. Reviewed in Science vol 287, p1883.
1997 & 1998  Doctoral student Foerderer fellowship, Thomas Jefferson University, USA
 

Selected Publications: 

J. O’Sullivan, S. D’Arcy, F. P. Barry, J.M. Murphy, C.M. Coleman. Mesenchymal Chondroprogenitor Cell Origin, Isolation and Therapeutic Potential. Accepted: Stem Cell Research & Therapy, 2011.

E. Vaughan, A. Liew, K. Mashayekh, P. Dockery, J. McDermott, B. Kealy, A. Flynn, A. Duffy, C. M. Coleman, A. O’Regan, F. Barry, T. O’Brien. Pre-treatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease. Accepted: Cell Transplantation, 2010.

C. M. Coleman, B.H. Scheremeta, A. T Boyce, R. M. Mauck, R. S. Tuan. 2010. Fracture Healing in GDF-5 Deficient Mice. Accepted: Clinical Orthopaedics and Related Research, 2010.

C.M. Coleman, C. Curtin, F. Barry, J.M. Murphy. 2010. Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice? Human Gene Therapy 21(10):1239-1250.

C.M. Coleman. 2008. Chicken Embryo as a Model for Regenerative Medicine. Birth Defects Research (Part C) 84:245-256.

A. Flynn, P. Sloane, C. M. Coleman, A. Stocca, L. Mylotte, J. Boucher, G. Shaw, A. Magee, C. McHale, P. Nolan, P. Nash, F. Barry, T. O’Brien. 2008 Elucidation of Engraftment and Efficacy of Syngeneic Mesenchymal Stem Cells in Rodent Myocardial Infarction. Manuscript in preparation.

A. Liew, T. Bowes, J. McDermott, B. Kealy, L. Howard, A. O’Regan, A. Flynn, C.M. Coleman, G. Avalos, F. Barry, T. O’Brien. 2008 Critical role for osteopontin in endothelial progenitor cell (EPC) mediated neovascularisation. Manuscript submitted to Arteriosclerosis, Thrombosis and Vascular Biology.

C.M. Coleman, G.A. Loredo, C.W. Lo and R.S. Tuan. 2003. Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development. Anatomical Record Part A. 275(A): 1117-1121.

C.M. Coleman and R.S. Tuan. 2003. Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation. Developmental Dynamics. 228(2): 208-216.

C.M. Coleman, G.A. Loredo, C.W. Lo and R.S. Tuan. 2003. Correlation of GDF5 and Connexin 43 mRNA Expression During Embryonic Development. Anatomical Record Part A. 275(A): 1117-1121.

C.M. Coleman and R.S. Tuan. 2003. Growth/Differentiation Factor 5 Enhances Chondrocyte Maturation. Developmental Dynamics. 228(2): 208-216.

C. M. Coleman and R.S. Tuan. 2003. Functional Role of Growth/Differentiation Factor 5 in Chondrogenesis of Limb Mesenchymal Cells. Mechanisms of Development. 120(7): 823-836.

L. Shum, C.M. Coleman, Y. Hatakeyama and R.S. Tuan. 2003. Morphogenesis and Dysmorphogenesis of the Appendicular Skeleton. Birth Defects Research (Part C). 69(2): 102-122.

B. Chatterjee, R.A. Meyer, G.A. Loredo, C.M. Coleman, R.S. Tuan and C.W. Lo. 2003. BMP Regulation of the Mouse Connexin-43 Promoter in Osteoblastic Cells and Embryos. Cell Adhesion and Communication. 10(1): 37-50.

Research Funding: 

Research funding Secured

Science Foundation Ireland: Centre for Science, Engineering and Technology: The Regenerative Medicine Institute (REMEDI): 2004-2008. Senior Scientist investigating several cardiovascular therapies. €19 million grant obtained by Professor Tim O’Brien.

Professional and Personal Interests: 

Orthopaedic Research Society                                                  Society for Developmental Biology                                        American Society of Cell Biology                                              Reviewer for Journal of Orthopaedic Research

Search PubMed for Papers by Dr. Cynthia Coleman >>