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Dr. Bernard Mahon

Dean of Science, NUI Maynooth
Phone: 
+353-1-708-3835
bpmahon@nuim.ie

Mucosal Immunology Laboratory, NUI Maynooth

Examination of the neonatal immune response. We explore how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation).

Researcher in

Research Project Area: 

The Mucosal Immunology Laboratory, NUI Maynooth examines the neonatal immune response. This has grown out of our interests in childhood immunisation. We have examined immunity in a number of diseases important during pregnancy (B19 virus) or early life ( B. pertussis ). This work has shown how immunity in early life can be different to that in adults and how pathogens can alter immune responses. Together with REMEDI from NUI Galway, we are exploring how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation). We believe that adult stem cells maintain many aspects of the fetal graft, which allows these cells to be successfully used in regenerative medicine. If we are correct it may mean that adult derived stem cells can be used in a wide variety of new therapies.

Positions Held: 

 http://biology.nuim.ie/staff/bmmucosal.shtml

2003 - Present  P.I, REMEDI, NUI, Galway, Collaborative Research Projects with REMEDI

1994 - Present   Immunologist, Institute of Immunology, NUI, Maynooth

2001 - 2006  Scientific Director, Institute of Immunology, NUIM

1990 - 1994  Ph.D in Immunology, OU

Awards & Honours: 

2009  Servier Scholarship for Collaborative Work, Institut Pasteur de Lille, France

Wellcome Trust/HRB  New Blood Fellow, NUI, Maynooth

Selected Publications: 

Skerry CM, and B.P. Mahon. 'A live attenuated Bordetella pertussis vaccine provides long term protection against virulent challenge in a murine model.' Clinical And Vaccine Immunology, in press (2011)
 

•English K, Mahon BP, and K.J. Woods 'Mesenchymal Stromal Cells: Role in Tissue Repair, Drug Discovery and Transplantation Tolerance. ' Current Drug Delivery in press (2011)
 

Griffin MD, Ritter T, and B.P. Mahon 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies.' Human Gene Therapy 21 pp 1641-1655 (2010)

•Kavanagh H., and B.P. Mahon. 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming.' Inernational Drug Discovery 5 pp 46-51 (2010)
 

English, K., J.R. Ryan, L. Tobin, M.J. Murphy, F.P. Barry and B.P. Mahon. 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells.' Clinical And Experimental Immunology 156 pp 149-160 (2009)

•Molloy, E.L., Adams, A., Moore, J.B., Masterson, J.C., Madrigal-Estebas, L., Mahon, B.P. and O’Dea, S. 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells. ' Growth Factors 26 pp 12-22 (2008)
 

K. English, F. P. Barry and B. P. Mahon. 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function.' Immunology Letters 115 pp 50-58 (2008)

English K, Barry FP, Mahon BP. Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation.
Immunol Lett. 2008 Jan 15;115(1):50-8. Epub 2007 Oct 31.

F.P. Barry, J.M. Murphy, T. OBrien and B.P. Mahon. Mesenchymal Stem Cell Transplantation for Tissue Repair. Seminars in Plastic Surgery 19, 229-240 (2005).

English, K. C.M. Brady, P. Corcoran, J.P. Cassidy and B.P. Mahon. Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma. Immunology Letters 103, 92-100 (2006).

J. Ryan, F.P. Barry, J.M. Murphy and B.P. Mahon. Mesenchymal stem cells avoid allogeneic rejection. Journal of Inflammation 2(8), 1-11 (2005).

F.P. Barry, J.M. Murphy, K. English and B.P. Mahon. Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. Stem Cells and Development 14, 252-65 (2005).

Professional and Personal Interests: 

Stem Cell Immunology, Vaccine design

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