PrincipaI Investigator, Mucosal Immunology Laboratory, NUI Maynooth
Examination of the neonatal immune response. We explore how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation).
Researcher in
Our group examines the neonatal immune response. This has grown out of our interests in childhood immunisation. We have examined immunity in a number of diseases important during pregnancy (B19 virus) or early life ( B. pertussis ). This work has shown how immunity in early life can be different to that in adults and how pathogens can alter immune responses. Together with REMEDI from NUI Galway. we are exploring how adult derived stem cells can be transplanted even when mismatched (allogeneic transplantation). We believe that adult stem cells maintain many aspects of the fetal graft, which allows these cells to be successfully used in regenerative medicine. If we are correct it may mean that adult derived stem cells can be used in a wide variety of new therapies.
English K, Barry FP, Mahon BP. Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation.
Immunol Lett. 2008 Jan 15;115(1):50-8. Epub 2007 Oct 31.
F.P. Barry, J.M. Murphy, T. OBrien and B.P. Mahon. Mesenchymal Stem Cell Transplantation for Tissue Repair. Seminars in Plastic Surgery 19, 229-240 (2005).
English, K. C.M. Brady, P. Corcoran, J.P. Cassidy and B.P. Mahon. Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma. Immunology Letters 103, 92-100 (2006).
J. Ryan, F.P. Barry, J.M. Murphy and B.P. Mahon. Mesenchymal stem cells avoid allogeneic rejection. Journal of Inflammation 2(8), 1-11 (2005).
F.P. Barry, J.M. Murphy, K. English and B.P. Mahon. Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. Stem Cells and Development 14, 252-65 (2005).