Cancer exploiting complement: a clue or an exception?

Nature Immunology 9, 1205 (2008). doi:10.1038/ni1108-1205

Authors: Bruce E Loveland
& Jonathan Cebon

Cancer cells are more resistant to complement-mediated lysis and use this attribute to set up a locally immunosuppressive environment. However, new findings suggest that tumor-driven complement activation can also provide the tumor a growth advantage.